Last edited by Grozilkree
Saturday, May 9, 2020 | History

6 edition of Wnt Signaling in Development found in the catalog.

Wnt Signaling in Development

by Michael KГјhl

  • 320 Want to read
  • 17 Currently reading

Published by Springer .
Written in English

    Subjects:
  • Cellular biology,
  • Medical,
  • Science,
  • Life Sciences - Biochemistry,
  • Life Sciences - Biology - Developmental Biology,
  • Life Sciences - Biology - Molecular Biology,
  • Science / Biochemistry,
  • General,
  • Cellular signal transduction,
  • Developmental cytology,
  • Developmental genetics,
  • Wnt genes,
  • Wnt proteins

  • Edition Notes

    Molecular Biology Intelligence Unit

    The Physical Object
    FormatHardcover
    Number of Pages280
    ID Numbers
    Open LibraryOL9463634M
    ISBN 100306478382
    ISBN 109780306478383

    Wnt proteins are able to activate different intracellular signaling cascades. This book describes different aspects of Wnt signaling during development of different species like the mouse, Xenopus, chicken, C. elegans or Drosophila and in different cellular contexts like heart formation or limb bud patterning. Wnt proteins are now recognized as one of the major families of developmentally important signaling molecules, with mutations in Wnt genes displaying remarkable phenotypes in the mouse, Caenorhabditis elegans, and Drosophila. Among functions provided by Wnt proteins are such intriguing processes as embryonic induction, the generation of cell polarity, and the specification of cell by:

    The Wnt pathway is an evolutionarily conserved signaling network that is critical for mammalian development and adult tissue maintenance, and, importantly, hyperactivated in most human cancers. Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion.

    Wnt /beta-catenin signaling mechanism. The stability of cytoplasmic β-catenin is critical for the signaling output of Wnt signaling. β-catenin ( amino acids) consists of central region of amino acids made up of armadillo repeats, flanked by distinct N- and C-terminal domains (NTD and CTD). Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development. Recent advances have expanded the role of WNT to a wide range of pathologies in humans. Here, we discuss the WNT pathway and its role in human disease and some of the advances in WNT-related by: 7.


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Wnt Signaling in Development by Michael KГјhl Download PDF EPUB FB2

Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before.

Brief introduction of Wnt signaling pathways in development and disease. One of the most remarkable biological processes is the formation of a morphologically complex and functional diverse multicellular organism such as a human being from a single fertilized egg within a short period of by: Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease.

Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion Cited by: Wnt signaling in stem cells plays critical roles in development, normal adult physiology, and disease.

In this chapter, we focus on the role of the Wnt signaling pathway in somatic stem cell biology and its critical role in normal tissue homeostasis and cancer.

Wnt signaling can both maintain potency and initiate differentiation in somatic stem. Mechanisms of Wnt signaling in development.

Wodarz A(1), Nusse R. Author information: (1)Institut für Genetik, Universität Düsseldorf, Germany. [email protected] Wnt genes encode a large family of secreted, cysteine-rich proteins that play key roles as intercellular signaling molecules in by: Wnt Signaling in Limb Development / Christine Hartmann Wnt/Wg and Heart Development / Petra Pandur and Michael Kuhl Wnt Signaling in C.

elegans / Michael A. Herman The Wnt Gene Family and the Evolutionary Conservation of Wnt Expression / Michael Schubert and Linda Z. Holland. The Wnt/BAR-1 pathway is primarily required during larval development, with functions in Q neuroblast migration, vulva development, P12 fate specification, and the generation of seam cell-derived structures such as the postdeirid and male rays (see the WormBook chapter Wnt signaling; Korswagen, ).

Wnt signaling clearly exists in C. elegans, utilizing the β-cateninBAR However, a noncanonical pathway utilizing the β-cateninWRM-1 also exists, and to date a similar pathway has not been described in other species.

Evidence for β-catenin independent noncanonical Wnt signaling is File Size: 1MB. Wnt proteins are able to activate different intracellular signaling cascades.

This book describes different aspects of Wnt signaling during development of different species like the mouse, Xenopus, chicken, C. elegans or Drosophila and in different cellular contexts like heart formation or limb bud : Springer US.

Search in this book series. Wnt Signaling in Embryonic Development. Sergei Y. Sokol. Vol Pages () Download full volume. Previous volume.

Multiple roles for Wnt signaling in the development of the vertebrate neural crest. Elizabeth Heeg‐Truesdell, Carole LaBonne. EMBO Journal () published a special focus issue on Wnt signaling, on the occasion of the 30th anniversary of the field.

It contains six reviews of various areas of Wnt signaling. Cold Spring Harbor Perspectives in Biology () has published a series of reviews on Wnt signaling and a book on the field. Nusse, R. & Varmus, H. A superb compilation of reviews from leading experts in the field of Wnt signaling (signaling molecules that regulate cell-to-cell interactions during embryogenesis), volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of research on Wnt signaling.

Written by specialists in the field, these chapters cover different levels of Author: Sergei Sokol. Purchase Wnt Signaling in Embryonic Development, Volume 17 - 1st Edition. Print Book & E-Book.

ISBN  While Wnt/β-catenin signaling is known to be involved in the development of neural crest cells in zebrafish, it is unclear which Wnts are involved, and when they are required.

To address these issues we employed a zebrafish line that was transgenic for an inducible inhibitor of Wnt/β-catenin signaling, and inhibited endogenous Wnt/β-catenin signaling at discrete times in by: catenin-mediated Wnt signaling has been suggested to be critically involved in hematopoietic stem cell maintenance and development of T and B cells in the immune system.

Get this from a library. Wnt signaling in embryonic development. [Sergei Y Sokol;] -- A superb compilation of reviews from leading experts in the field of Wnt signaling, volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of.

A superb compilation of reviews from leading experts in the field of Wnt signaling (signaling molecules that regulate cell-to-cell interactions during embryogenesis), volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of research on Wnt signaling.

Written by specialists in the field, these chapters cover different levels of Format: Hardcover. β‐catenin was discovered independently by researchers investigating the molecular basis of cadherin cell adhesion in vertebrate epithelial cells and through genetic screens in Drosophila for mutants with defective embryonic segmentation, which was subsequently discovered to be a Wnt dependent signaling event.

A major role for β‐catenin is at the cell‐cell adhesion junctions between. Wnt signalling in the development of axon, dendrites and synapses Abstract In recent years, mounting evidence has revealed important functions of Wnt signalling in diverse aspects of neural development, including neuronal polarization, guidance and branching of the axon and dendrites, as well as synapse formation and its structural by:   Cancer development depends on the aberrant activation of signal transduction pathways that control cell growth and survival and play important roles in normal embryonic development.

This review will focus on one of the most powerful pathways, the canonical Wnt signal transduction cascade, which has been originally described in vertebrate and non-vertebrate embryogenesis and Cited by:. Wnt signaling is also crucial in the nervous system development including neurogenesis, neuronal polarization, neurite outgrowth, axon guidance and synapse formation (He et al., ;Inestrosa and Author: Yingzi Yang.Role in Development.

Wnt6 plays a role in the formation and maturation of different embryonic structures, namely the fetal heart, ventral body wall, and somite derived structures.

Wnt6, through the canonical Wnt signaling pathway, inhibits the induction of cardiogenic :   Combinatorial signaling is an important mechanism that allows the embryo to utilize overlapping signaling pathways to specify different territories. In zebrafish, the Wnt and Bmp pathways interact to regulate the formation of the posterior body.

In order to understand how this works mechanistically, we have identified tbx6 as a posterior mesodermal gene activated by both of these Cited by: